Therapeutic Angiogenesis in Patients with Stage IIb Chronic Arterial Insufficiency

Abstract

Introduction: Atherosclerosis obliterans is the most common cause of arterial occlusive disease in adults. Neovascularization of ischemic muscles may be sufficient to preserve their integrity; therefore, it has been the basis for the development of new strategies, including therapeutic angiogenesis.

Objective: To evaluate the effect of angiogenic therapy in patients with stage IIb chronic arterial insufficiency.

Methods: A quasiexperimental before-and-after study was carried out in patients with stage IIb chronic arterial insufficiency treated with granulocyte colony growth factor (G-CSF) in the angiology and vascular surgery service of Hospital General Docente Enrique Cabrera in 2023. The sample consisted of 34 patients who received treatment with G-CGF and who met the inclusion and exclusion criteria.

Results: Men reached 52.9 %, compared to women, who reached 47.1 %; the age group between 61 and 70 years, 44.1 %. Hypertension and smoking showed a 79.4 %. 70.6 % of the patients were in the lower range of the ankle-brachial pressure index at baseline. At one year, 55.9 % were between 0.9 and 1, and 79.4 % achieved a range between 50-149. At closure, 70.6 % achieved between 250 and 350 ms.

Conclusions: There was a slight majority of men and the 61-70 years’ age group was more frequent. Tobacco addiction and arterial hypertension were the most relevant risk factors. In the ankle-brachial index, most patients started with a minimum of 0.3 and, after the procedure, they reached a maximum of 1.0. From the beginning to the end of the procedure, a minimum distance of 50 to a maximum of 350 elapsed. The leukogram ranged from a majority of no more than 10 thousand/mm³ to 21 thousand/mm³ at the sixth day.